| Farquhar John C.M.Director, Chief Executive Officer | Open-market or private sale (S)Table I · Disposed · Common Stock | 38,900 | $49.568 | $1,928,195 | 283,014 | Oct 12, 2026 | 1 filed lot- Table I · Common Stock: 38,900 shares at $49.568 · code S · owned after 283,014 ·
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| Rogers CampbellChief Medical Officer | Exercise or conversion of derivative security (M)Table I · Acquired · Common Stock · 2 paired events | 13,179 | $7.9359 | $104,588 | See lot detail | Sep 18, 2026 | 2 filed lots- Table I · Common Stock: 12,329 shares at $8.33 · code M · owned after 98,788 · Paired event: 12,329 Stock Option → 12,329 Common Stock ·
- Table I · Common Stock: 850 shares at $2.22 · code M · owned after 99,638 · Paired event: 850 Stock Option → 850 Common Stock ·
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| Rogers CampbellChief Medical Officer | Open-market or private sale (S)Table I · Disposed · Common Stock | 19,682 | $50.15 | $987,052 | 79,956 | Sep 18, 2026 | 1 filed lot- Table I · Common Stock: 19,682 shares at $50.15 · code S · owned after 79,956 ·
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| Rogers CampbellChief Medical Officer | Exercise or conversion of derivative security (M)Table II · Disposed · Stock Option · 2 paired events | 13,179 | —Exercise or conversion of derivative security (M) | — | See lot detail | Sep 18, 2026 | 2 filed lots- Table II · Stock Option: 12,329 shares at — (Exercise or conversion of derivative security (M)) · code M · owned after 31,456 · Paired event: 12,329 Stock Option → 12,329 Common Stock ·
- Table II · Stock Option: 850 shares at — (Exercise or conversion of derivative security (M)) · code M · owned after 70,783 · Paired event: 850 Stock Option → 850 Common Stock ·
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| Verghese VikramChief Financial Officer | Open-market or private sale (S)Table I · Disposed · Common Stock. | 16,766 | $50.7531 | $850,926 | 155,183 | Sep 18, 2026 | 1 filed lot- Table I · Common Stock.: 16,766 shares at $50.7531 · code S · owned after 155,183 ·
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| Verghese VikramChief Financial Officer | Open-market or private sale (S)Table I · Disposed · Common Stock. | 7,579 | $50.1142 | $379,816 | 171,949 | Sep 17, 2026 | 1 filed lot- Table I · Common Stock.: 7,579 shares at $50.1142 · code S · owned after 171,949 ·
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| Verghese VikramChief Financial Officer | Open-market or private sale (S)Table I · Disposed · Common Stock. | 668 | $50.012 | $33,408 | 179,528 | Sep 15, 2026 | 1 filed lot- Table I · Common Stock.: 668 shares at $50.012 · code S · owned after 179,528 ·
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| Verghese VikramChief Financial Officer | Open-market or private sale (S)Table I · Disposed · Common Stock. | 4,593 | $50.2381 | $230,744 | 180,196 | Sep 14, 2026 | 1 filed lot- Table I · Common Stock.: 4,593 shares at $50.2381 · code S · owned after 180,196 ·
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| Verghese VikramChief Financial Officer | Open-market or private sale (S)Table I · Disposed · Common Stock. | 29,714 | $50.0592 | $1,487,459 | 184,789 | Sep 11, 2026 | 1 filed lot- Table I · Common Stock.: 29,714 shares at $50.0592 · code S · owned after 184,789 ·
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| Farquhar John C.M.Director, Chief Executive Officer | Open-market or private sale (S)Table I · Disposed · Common Stock | 3,890 | $50.00 | $194,500 | 321,914 | Sep 11, 2026 | 1 filed lot- Table I · Common Stock: 3,890 shares at $50.00 · code S · owned after 321,914 ·
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| Farquhar John C.M.Director, Chief Executive Officer | Open-market or private sale (S)Table I · Disposed · Common Stock | 35,010 | $46.4183 | $1,625,105 | 325,804 | Sep 10, 2026 | 1 filed lot- Table I · Common Stock: 35,010 shares at $46.4183 · code S · owned after 325,804 ·
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| Verghese VikramChief Financial Officer | Open-market or private sale (S)Table I · Disposed · Common Stock. | 6,640 | $50.0319 | $332,212 | 214,503 | Sep 8, 2026 | 1 filed lot- Table I · Common Stock.: 6,640 shares at $50.0319 · code S · owned after 214,503 ·
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| Verghese VikramChief Financial Officer | Open-market or private sale (S)Table I · Disposed · Common Stock. | 27,540 | $49.6903 | $1,368,471 | 221,143 | Sep 3, 2026 | 1 filed lot- Table I · Common Stock.: 27,540 shares at $49.6903 · code S · owned after 221,143 ·
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| Verghese VikramChief Financial Officer | Open-market or private sale (S)Table I · Disposed · Common Stock. | 5,876 | $50.60 | $297,326 | 248,683 | Sep 2, 2026 | 1 filed lot- Table I · Common Stock.: 5,876 shares at $50.60 · code S · owned after 248,683 ·
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| Farquhar John C.M.Director, Chief Executive Officer | Open-market or private sale (S)Table I · Disposed · Common Stock | 27,230 | $50.00 | $1,361,500 | 360,814 | Aug 21, 2026 | 1 filed lot- Table I · Common Stock: 27,230 shares at $50.00 · code S · owned after 360,814 ·
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| Farquhar John C.M.Director, Chief Executive Officer | Open-market or private sale (S)Table I · Disposed · Common Stock | 32,676 | $45.00 | $1,470,420 | 388,044 | Aug 18, 2026 | 1 filed lot- Table I · Common Stock: 32,676 shares at $45.00 · code S · owned after 388,044 ·
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| Rogers CampbellChief Medical Officer | Exercise or conversion of derivative security (M)Table I · Acquired · Common Stock · 1 paired event | 9,219 | $19.00 | $175,161 | 95,678 | Aug 17, 2026 | 1 filed lot- Table I · Common Stock: 9,219 shares at $19.00 · code M · owned after 95,678 · Paired event: 9,219 Stock Options → 9,219 Common Stock ·
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| Rogers CampbellChief Medical Officer | Open-market or private sale (S)Table I · Disposed · Common Stock | 9,219 | $41.23 | $380,099 | 86,459 | Aug 17, 2026 | 1 filed lot- Table I · Common Stock: 9,219 shares at $41.23 · code S · owned after 86,459 ·
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| Rogers CampbellChief Medical Officer | Exercise or conversion of derivative security (M)Table II · Disposed · Stock Options · 1 paired event | 9,219 | —Exercise or conversion of derivative security (M) | — | 82,972 | Aug 17, 2026 | 1 filed lot- Table II · Stock Options: 9,219 shares at — (Exercise or conversion of derivative security (M)) · code M · owned after 82,972 · Paired event: 9,219 Stock Options → 9,219 Common Stock ·
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| Farquhar John C.M.Director, Chief Executive Officer | Open-market or private sale (S)Table I · Disposed · Common Stock | 15,560 | $39.06 | $607,774 | 420,720 | Aug 14, 2026 | 1 filed lot- Table I · Common Stock: 15,560 shares at $39.06 · code S · owned after 420,720 ·
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| Farquhar John C.M.Director, Chief Executive Officer | Open-market or private sale (S)Table I · Disposed · Common Stock | 22,562 | $28.31 | $638,730 | 436,280 | Aug 10, 2026 | 1 filed lot- Table I · Common Stock: 22,562 shares at $28.31 · code S · owned after 436,280 ·
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| Jones Marie L.Chief Accounting Officer | Payment of exercise price or tax liability (F)Table I · Disposed · Common Stock. | 82 | $28.82 | $2,363 | 32,176 | Aug 7, 2026 | 1 filed lot- Table I · Common Stock.: 82 shares at $28.82 · code F · owned after 32,176 ·
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| Verghese VikramChief Financial Officer | Payment of exercise price or tax liability (F)Table I · Disposed · Common Stock. | 473 | $28.82 | $13,632 | 254,559 | Aug 7, 2026 | 1 filed lot- Table I · Common Stock.: 473 shares at $28.82 · code F · owned after 254,559 ·
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| Rogers CampbellChief Medical Officer | Payment of exercise price or tax liability (F)Table I · Disposed · Common Stock | 637 | $28.82 | $18,358 | 86,459 | Aug 7, 2026 | 1 filed lot- Table I · Common Stock: 637 shares at $28.82 · code F · owned after 86,459 ·
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| Farquhar John C.M.Director, Chief Executive Officer | Payment of exercise price or tax liability (F)Table I · Disposed · Common Stock | 1,904 | $28.82 | $54,873 | 458,842 | Aug 7, 2026 | 1 filed lot- Table I · Common Stock: 1,904 shares at $28.82 · code F · owned after 458,842 ·
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| Jones Marie L.Chief Accounting Officer | Payment of exercise price or tax liability (F)Table I · Disposed · Common Stock. | 486 | $27.19 | $13,214 | 32,258 | Aug 6, 2026 | 1 filed lot- Table I · Common Stock.: 486 shares at $27.19 · code F · owned after 32,258 ·
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| Verghese VikramChief Financial Officer | Payment of exercise price or tax liability (F)Table I · Disposed · Common Stock. | 1,537 | $27.19 | $41,791 | 255,032 | Aug 6, 2026 | 1 filed lot- Table I · Common Stock.: 1,537 shares at $27.19 · code F · owned after 255,032 ·
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| Rogers CampbellChief Medical Officer | Payment of exercise price or tax liability (F)Table I · Disposed · Common Stock | 1,635 | $27.19 | $44,456 | 87,096 | Aug 6, 2026 | 1 filed lot- Table I · Common Stock: 1,635 shares at $27.19 · code F · owned after 87,096 ·
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| Farquhar John C.M.Director, Chief Executive Officer | Payment of exercise price or tax liability (F)Table I · Disposed · Common Stock | 5,847 | $27.19 | $158,980 | 460,746 | Aug 6, 2026 | 1 filed lot- Table I · Common Stock: 5,847 shares at $27.19 · code F · owned after 460,746 ·
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| Jones Marie L.Chief Accounting Officer | Grant, award, or other acquisition (A)Table I · Acquired · Common Stock. | 1,661 | $16.15 | $26,825 | 33,311 | Mar 6, 2026 | 1 filed lot- Table I · Common Stock.: 1,661 shares at $16.15 · code A · owned after 33,311 ·
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| Verghese VikramChief Financial Officer | Grant, award, or other acquisition (A)Table I · Acquired · Common Stock. | 671 | $16.15 | $10,837 | 213,534 | Mar 6, 2026 | 1 filed lot- Table I · Common Stock.: 671 shares at $16.15 · code A · owned after 213,534 ·
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