| Farquhar John C.M.Director, Chief Executive Officer | Open-market or private sale (S)Table I · Disposed · Common Stock | 27,230 | $50.00 | $1,361,500 | 360,814 | Aug 21, 2026 | 1 filed lot- Table I · Common Stock: 27,230 shares at $50.00 · code S · owned after 360,814 ·
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| Farquhar John C.M.Director, Chief Executive Officer | Open-market or private sale (S)Table I · Disposed · Common Stock | 32,676 | $45.00 | $1,470,420 | 388,044 | Aug 18, 2026 | 1 filed lot- Table I · Common Stock: 32,676 shares at $45.00 · code S · owned after 388,044 ·
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| Rogers CampbellChief Medical Officer | Exercise or conversion of derivative security (M)Table I · Acquired · Common Stock · 1 paired event | 9,219 | $19.00 | $175,161 | 95,678 | Aug 17, 2026 | 1 filed lot- Table I · Common Stock: 9,219 shares at $19.00 · code M · owned after 95,678 · Paired event: 9,219 Stock Options → 9,219 Common Stock ·
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| Rogers CampbellChief Medical Officer | Open-market or private sale (S)Table I · Disposed · Common Stock | 9,219 | $41.23 | $380,099 | 86,459 | Aug 17, 2026 | 1 filed lot- Table I · Common Stock: 9,219 shares at $41.23 · code S · owned after 86,459 ·
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| Rogers CampbellChief Medical Officer | Exercise or conversion of derivative security (M)Table II · Disposed · Stock Options · 1 paired event | 9,219 | —Exercise or conversion of derivative security (M) | — | 82,972 | Aug 17, 2026 | 1 filed lot- Table II · Stock Options: 9,219 shares at — (Exercise or conversion of derivative security (M)) · code M · owned after 82,972 · Paired event: 9,219 Stock Options → 9,219 Common Stock ·
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| Farquhar John C.M.Director, Chief Executive Officer | Open-market or private sale (S)Table I · Disposed · Common Stock | 15,560 | $39.06 | $607,774 | 420,720 | Aug 14, 2026 | 1 filed lot- Table I · Common Stock: 15,560 shares at $39.06 · code S · owned after 420,720 ·
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| Farquhar John C.M.Director, Chief Executive Officer | Open-market or private sale (S)Table I · Disposed · Common Stock | 22,562 | $28.31 | $638,730 | 436,280 | Aug 10, 2026 | 1 filed lot- Table I · Common Stock: 22,562 shares at $28.31 · code S · owned after 436,280 ·
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| Jones Marie L.Chief Accounting Officer | Payment of exercise price or tax liability (F)Table I · Disposed · Common Stock. | 82 | $28.82 | $2,363 | 32,176 | Aug 7, 2026 | 1 filed lot- Table I · Common Stock.: 82 shares at $28.82 · code F · owned after 32,176 ·
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| Verghese VikramChief Financial Officer | Payment of exercise price or tax liability (F)Table I · Disposed · Common Stock. | 473 | $28.82 | $13,632 | 254,559 | Aug 7, 2026 | 1 filed lot- Table I · Common Stock.: 473 shares at $28.82 · code F · owned after 254,559 ·
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| Rogers CampbellChief Medical Officer | Payment of exercise price or tax liability (F)Table I · Disposed · Common Stock | 637 | $28.82 | $18,358 | 86,459 | Aug 7, 2026 | 1 filed lot- Table I · Common Stock: 637 shares at $28.82 · code F · owned after 86,459 ·
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| Farquhar John C.M.Director, Chief Executive Officer | Payment of exercise price or tax liability (F)Table I · Disposed · Common Stock | 1,904 | $28.82 | $54,873 | 458,842 | Aug 7, 2026 | 1 filed lot- Table I · Common Stock: 1,904 shares at $28.82 · code F · owned after 458,842 ·
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| Jones Marie L.Chief Accounting Officer | Payment of exercise price or tax liability (F)Table I · Disposed · Common Stock. | 486 | $27.19 | $13,214 | 32,258 | Aug 6, 2026 | 1 filed lot- Table I · Common Stock.: 486 shares at $27.19 · code F · owned after 32,258 ·
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| Verghese VikramChief Financial Officer | Payment of exercise price or tax liability (F)Table I · Disposed · Common Stock. | 1,537 | $27.19 | $41,791 | 255,032 | Aug 6, 2026 | 1 filed lot- Table I · Common Stock.: 1,537 shares at $27.19 · code F · owned after 255,032 ·
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| Rogers CampbellChief Medical Officer | Payment of exercise price or tax liability (F)Table I · Disposed · Common Stock | 1,635 | $27.19 | $44,456 | 87,096 | Aug 6, 2026 | 1 filed lot- Table I · Common Stock: 1,635 shares at $27.19 · code F · owned after 87,096 ·
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| Farquhar John C.M.Director, Chief Executive Officer | Payment of exercise price or tax liability (F)Table I · Disposed · Common Stock | 5,847 | $27.19 | $158,980 | 460,746 | Aug 6, 2026 | 1 filed lot- Table I · Common Stock: 5,847 shares at $27.19 · code F · owned after 460,746 ·
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| Jones Marie L.Chief Accounting Officer | Grant, award, or other acquisition (A)Table I · Acquired · Common Stock. | 1,661 | $16.15 | $26,825 | 33,311 | Mar 6, 2026 | 1 filed lot- Table I · Common Stock.: 1,661 shares at $16.15 · code A · owned after 33,311 ·
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| Verghese VikramChief Financial Officer | Grant, award, or other acquisition (A)Table I · Acquired · Common Stock. | 671 | $16.15 | $10,837 | 213,534 | Mar 6, 2026 | 1 filed lot- Table I · Common Stock.: 671 shares at $16.15 · code A · owned after 213,534 ·
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