Septerna, Inc.
SEPN · Healthcare · $1.4B mkt cap · FY2025 filings · No moat ·
Doesn't clear the bar
The five investor questions
2023–2025: revenue 151000.00 to 45951000.00, increasing; diluted EPS 0.29 to -1.10, decreasing. Latest-filed diluted EPS remains usable for Business Trend, but an integer share-count change lacks enough evidence to confirm a comparable EPS basis; valuation growth therefore stays at 0%.
Not enough years of gross-margin data to score pricing power.
Median ROIC -27.9%, above the 12% hurdle in 0% of years.
Net cash position — no leverage risk.
Owner earnings trend unclear, share count growing (dilution).
The pricingPower component abstained: Not enough years of gross-margin data to score pricing power. The other four 20% weights were renormalized over the scored 80%.
Price vs. owner-earnings value range
- Owner earnings (normalized)
- —
- Value range / share
- —
- Conservative high estimate / share
- —
- Recent price
- $32.21
- Price vs. high estimate
- No price data
Conservative range under moat-index@2.0.0: low end 11.1×, high end capped at 18×; 9% discount rate; high-end growth 0% (capped at 4%) using min(5y revenue CAGR, 5y diluted-EPS CAGR), clamped to 0%–4%; maintenance capex uses min(capex, D&A); abstain when D&A is unavailable. This is a disclosed model range, not intrinsic value as fact.
4 years of fundamentals
The business, in plain English
SEPN's filings don't disclose total debt in a form the methodology can use, so leverage is treated as unmeasured — never assumed to be zero.
This breakdown is generated from the filed numbers and sub-scores above — no outside narrative, no estimates. Where a filing doesn’t disclose an input, the sentence that would need it is omitted instead of guessed.
Not disclosed in SEPN’s filings for these years — we don’t estimate it.
Gaps in a line mean that item isn’t in SEPN’s filings for that year — the series is never interpolated or estimated. The Table view lists every filed value, including operating and net margins, total debt, and share count.
Moat Score history
Tier changesSame-methodology crossings of the Wide / Narrow / Shallow bars
- Methodology upgraded moat-index@1.2.0tomoat-index@2.0.0 — readings across versions aren’t comparedJul 20, 2026
Scores are logged append-only and never overwritten — this record can’t be backfilled, which is exactly why it’s worth keeping.
Track record
How Septerna, Inc.’s moat rated in each of the years we can reconstruct from its filings — scored only on what was knowable at the time — and what its price and returns did afterward. The score never saw a price; the two are joined only in hindsight, for education, not as a signal.
How to read this: each dot is what the engine would have scored SEPN on that December 31; the line below is its total-return price path (dividends reinvested) in the years since.
Two tracks, one timeline: the score has its own 0–100 scale (top), the price its own 100-based scale (bottom) — never a shared axis. The indexed price path isn't available for this company yet; gaps in the score line are years with no reconstructed rating (see the table for why). The Table view carries every value.
What followed, in the years it rated Wide
In the reconstructed history shown, SEPN did not rate Wide-moat in any year, so there is no wide-moat track record to report. That absence is itself the honest answer — we don’t manufacture a comparison where the rating never earned one.
Healthcare context
#396 of 736 scored Healthcare companies, ranked by Moat Score.
Nearest peers by Moat Score
- #394JAZZ Jazz Pharmaceuticals plc39.2 out of 100, No moatNo moat
- #395AVTX Avalo Therapeutics, Inc.39.2 out of 100, No moatNo moat
- #397MGNX MACROGENICS, INC.39.1 out of 100, No moatNo moat
- #398ABVC ABVC BioPharma, Inc.39.1 out of 100, No moatNo moat
Compare SEPN with its nearest peers →All Healthcare companies on the Index →
Common questions about SEPN
- Does Septerna, Inc. have an economic moat?
- Based on its FY2025 SEC filings, the Moat Index scores Septerna, Inc. (SEPN) 39.2 out of 100 — below the Shallow-moat bar, so no moat. The five questions behind that score begin at 20% each; if exactly one genuinely lacks data, the other four weights are renormalized and disclosed. revenue and EPS trend 60, pricing power not measurable from the filings, returns on capital 0, balance-sheet safety 55, capital discipline 42.
- How has SEPN's Moat Score changed over time?
- The record logs 5 readings since Jul 18, 2026; the latest reads 39.2 out of 100 (no moat). No tier changes on record yet. (A methodology upgrade on Jul 20, 2026 re-based the score; readings across engine versions aren't compared.) The history is append-only — readings are only ever added, never rewritten.