Flagship explainer

What drives ALNYLAM PHARMACEUTICALS, INC.’s return on equity?

ROE is five filed business factors multiplied together.

DuPont return on equity factor treeReturn on equity branches into tax burden, interest burden, operating margin, asset turnover, and the equity multiplier.Return on equity73%Tax burden97%net income ÷ pretax incomeInterest burden64%pretax ÷ operating incomeOperating margin14%operating income ÷ revenueAsset turnover0.81×revenue ÷ average assetsEquity multiplier10.75×average assets ÷ average equityAs of 2025-12-31 · 1 SEC filing sourceBuy Like Buffett · buylikebuffett.com
DuPont source inputs
InputValueFiscal yearSource
$314MFY2025
Income before tax$323MFY2025
Operating income$502MFY2025
$3.7BFY2025
Ending assets$5.0BFY2025
Beginning assets$4.2BFY2024
$789MFY2025
$67.1MFY2024
Source: · event Dec 31, 2025 · retrieved Jul 26, 2026 · annual-row source set
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